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This copper-binding tripeptide activates TGF-beta/SMAD pathway signaling, stimulates collagen I and III synthesis, upregulates TIMP-1 and TIMP-2 to protect collagen from degradation, and modulates gene expression across approximately 4,000 human genes

However, the body is generally very efficient at excreting excess B12 through urine without any issues

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There was also a small but significant decrease in tryptophan by 2.0 3.0 mol/L (95% CI 3.50.57 mol/L)